Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression | Nature Communications
A rational blueprint for the design of chemically-controlled protein switches | Nature Communications
Engineering precision nanoparticles for drug delivery | Nature Reviews Drug Discovery
Coronaviruses — drug discovery and therapeutic options | Nature Reviews Drug Discovery
Strategies and challenges for the next generation of antibody–drug conjugates | Nature Reviews Drug Discovery
Designing hydrogels for controlled drug delivery | Nature Reviews Materials
Design of protein-binding proteins from the target structure alone | Nature
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy | Nature Communications
Counting on natural products for drug design | Nature Chemistry
Exploring protein hotspots by optimized fragment pharmacophores | Nature Communications
Network-based approach to prediction and population-based validation of in silico drug repurposing | Nature Communications
A unified drug–target interaction prediction framework based on knowledge graph and recommendation system | Nature Communications
New strategy for drug discovery by large-scale association analysis of molecular networks of different species | Scientific Reports
A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening | Nature Communications
Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery | Nature Communications
Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety | Chemical Research in Toxicology
Machine learning models to accelerate the design of polymeric long-acting injectables | Nature Communications
A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes | Nature Communications
A genome-wide positioning systems network algorithm for in silico drug repurposing | Nature Communications
The emerging role of mass spectrometry-based proteomics in drug discovery | Nature Reviews Drug Discovery
Massively parallel de novo protein design for targeted therapeutics | Nature
Predictive validity in drug discovery: what it is, why it matters and how to improve it | Nature Reviews Drug Discovery
Using human genetics to improve safety assessment of therapeutics | Nature Reviews Drug Discovery
The expanding role for small molecules in immuno-oncology | Nature Reviews Drug Discovery
Late-stage C–H functionalization offers new opportunities in drug discovery | Nature Reviews Chemistry
